Effects of antihypertensive treatment on glucose metabolism International Symposium, Bühlerhöhe, November 1988, [proceedings].

Cover of: Effects of antihypertensive treatment on glucose metabolism |

Published by Thieme in Stuttgart, New York .

Written in English

Read online

Edition Notes

Book details

SeriesHormone and metabolic research -- 22
ContributionsDietze, G. J.
The Physical Object
Pagination96p. :
Number of Pages96
ID Numbers
Open LibraryOL21816655M
ISBN 103137521017

Download Effects of antihypertensive treatment on glucose metabolism

The various classes of antihypertensive drugs have different effects on blood glucose metabolism. Indeed, antihypertensive agents, such as β-blockers and thiazide diuretics have been associated with negative effects on blood glucose in contrast to other classes, such as angiotensin receptor blockers (ARBs) and angiotensin converting enzyme Cited by: Effects of antihypertensive treatment on glucose metabolism: international symposium, Bühlerhöhe, November T1 - Effects of antihypertensives on glucose metabolism.

AU - Siegel, David. AU - Swislocki, Arthur L. PY - /9. Y1 - /9. N2 - Treatment with different antihypertensive drug classes has varied effects on glucose metabolism. Thiazide diuretic use in hypertensives has been associated with the development of glucose intolerance and by: The long-term use of hypotensive drugs may cause side effects, including impaired glucose metabolism and mineral status.

This study tested the hypothesis that some hypotensive drugs can affect tissular chromium levels and indices of glucose metabolic and antioxidant potential in by: 7.

Single-drug treatment of essential hypertension (HT) is often insufficient to normalize blood pressure (BP), and high doses of antihypertensive agents can have adverse effects on glucose tolerance (GT) and insulin sensitivity.

This study tested whether aggressive BP lowering with combination treatment had any influence on GT or insulin action. As a result the effects on glucose homeostasis of the various blood pressure lowering drugs should be taken into account when selecting an antihypertensive treatment.

Adverse metabolic effects have been associated with drugs used in the therapy of hypertension, especially diuretics and β-blockers. These effects include electrolyte, glucose/insulin, lipid and uric acid disturbances. This may explain, at least in part, why early trials examining the impact of antihypertensive pharmacotherapy with diuretics and β-blockers Cited by:   Glucose Tolerance Test.

Fig. 1 depicts plasma levels of glucose and insulin, basally and in response to oral glucose load. Baseline plasma insulin levels, but not glucose levels, were higher (P Cited by: Prazosin treatment was started with a low dose that was increased to attain an adequate blood pressure level within one to two months.

In nine patients, prazosin was substituted for hydralazine. Five months after the changes in therapy, lipid metabolism and glucose metabolism were again by: 6. Mounting research suggests that certain antihypertensive medications, such as thiazide diuretics, are associated with metabolic disturbances that result in increased glucose intolerance, while other antihypertensive medications, such as ACE inhibitors and ARBs, appear to improve insulin sensitivity and glucose metabolism.

CLINICAL THERAPEUTICS /VOL. 17, NO. 4, Effects of Long-Term Cilazapril Treatment on Glucose and Lipid Metabolism in Hypertensive Patients with Non-Insulin-Dependent Diabetes Mellitus Kenzo Uchida, MD, Toshikazu Kigoshi, MD, Takashi Ishii, MD, Mitsutaka Kitazawa, MD, Shigeru Nakano, MD, and Shinpei Morimoto, MD Division of Endocrinology, Department of Cited by: 1.

Pharmacological treatment of hypertension can cause clinically significant alterations in endocrine function through effects on glucose homeostasis, thyroid and parathyroid hormones, adrenal steroid metabolism and reproductive/pituitary physiology.

Long term use of thiazide diuretics causes deterioration in glucose tolerance, probably secondary to potassium Cited by: Initial clinical trials of antihypertensive regimens suggested that blood pressure lowering was the most important aspect of therapy and that the adverse effects on lipids and glucose tolerance.

Many CV drugs adversely affect glucose and lipid homeostasis, and insulin resistance is an important mediator of these adverse effects on glucose metabolism.

Direct RAS inhibitors (ARBs and ACEIs) and some other antihypertensives provide beneficial effects in terms of glucose homeostasis [ 88 ].Author: Nadya Merchant, Bobby V.

Khan. In patients with hypertension, sibutramine slightly increases BP and heart rate and should be used with caution. 44 However, another trial suggests that the effects of sibutramine in patients receiving antihypertensive treatment largely depend on the type of antihypertensive drug used.

45 Orlistat is an inhibitor of gastrointestinal lipases Author: Alejandro de la Sierra. However, the choice of an antihypertensive is controversial. Studies suggest that treatment with different antihypertensive drug classes may have varied effects on glucose and lipid metabolism.

Changes in insulin sensitivity are associated with adverse effects on glucose control [26, 27].Author: Arthur L.M. Swislocki, David Siegel. Abstract. Whereas individual research papers about antihypertensive treatment in diabetics might be somewhat confusing, the weight of the evidence strongly suggests that: 1) In patients with type 1 diabetes, it is advantageous to use angiotensin-converting enzyme (ACE) inhibitors as primary by: Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure).

Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial ce suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and.

The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and.

Glucose metabolism and antihypertensive medication ACE inhibitors and ARBs have a beneficial effect on glucose metabolism and suppress new onset of diabetes mellitus.

Thiazide diuretics increase our fasting glucose levels and have been associated with the development of glucose intolerance and diabetes. Barzilay JI, Davis BR, Cutler JA, et al. Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

Arch Intern Med. Nov 13;(20) Despite findings that aldosterone impairs glucose metabolism, studies concerning the effect of primary aldosteronism (PA) and its treatment on glucose metabolism are controversial.

We aimed to determine glucose metabolism in PA and the effect of the treatment modality. We compared glucose metabolism between PA patients (N = ) and age- sex- and body mass index Author: Mi Kyung Kwak, Jee Yang Lee, Beom-Jun Kim, Seung Hun Lee, Jung-Min Koh.

Overview Goals. The treatment goals are related to effective control of blood glucose, blood pressure and lipids, to minimize the risk of long-term consequences associated with are suggested in clinical practice guidelines released by various national and international diabetes agencies.

The targets are: Hb A1c of less than 6% or % if they are. Several clinical trials demonstrate that ARBs also have beneficial effects on glucose metabolism that are likely independent of bradykinin-mediated mechanisms.

In the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, losartan reduced the relative risk of developing type 2 diabetes by 25% when compared with the Cited by: 8. Sarafidis PA, Bakris GL. Antihypertensive treatment with beta-blockers and the spectrum of glycaemic control.

QJM ; Giordano M, Matsuda M, Sanders L, et al. Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension.

EFFECTS OF DIFFERENT ANTIHYPERTENSIVE AGENTS. Treatment of hypertension can affect lipid levels. Some antihypertensive drugs, for example, have a neutral or beneficial effect on the lipid profile, while others have an adverse effect; such adverse effects are outweighed by the beneficial effects of blood pressure lowering on cardiovascular risk.

Antihypertensive Drugs. The authors of this book look from different angles to hypertension, sharing their new knowledge and experience in the direction of deep understanding and more clarification of the disease providing an invaluable resource not only for clinicians, but also for all medical sciences students and health providers.

Risperidone tablets are indicated for the treatment of acute manic or mixed episodes associated with Bipolar I Disorder. Efficacy was established in 2 short-term trials in adults and one short-term trial in children and adolescents (ages 10 to 17 years) [see Clinical Studies () ].

Adjunctive Therapy. Risperidone tablets adjunctive therapy / Antihypertensive treatment reduces the risk of cardiovascular disease in people with diabetes mellitus, but the optimal blood pressure level has been debated WhAT ThIS STudy AddS In people with diabetes mellitus and a systolic blood pressure of more than mm Hg, antihypertensive treatment is associated with a reduced risk of mortality andCited by: Keywords: antihypertensive Therapie, Hypertonie, Insulinresistenz, Kardiologie, Risikofaktor, antihypertensive treatment, cardiology, hypertension, insulin resistance, risk factor management Essential hypertension is very frequently associated with an over-activity of the sympathetic nervous system (SNS) and a decrease in insulin sensitivity of skeletal muscle glucose uptake, Cited by: 2.

Several antihypertensive agent have been found to influence serum lipid profile (1,8,9,10,11,12,13) Indeed, a few studies claimed that the effects of antihypertensive agents on serum lipid might differ in different patient population (14) The present study was designed to evaluate the effect of the commonly used antihypertensive drugs on blood.

Although treatment for hypertension improves the QOL,the adverse effects of antihypertensive drugs reduce it. As treatment for hypertension continues over a. Antihypertensive drugs are used in the treatment of high blood pressure. Hypertension is not an insignificant diagnosis.

It is linked to a substantially increased risk of heart attack and stroke. Studies show, though, that even a modest reduction in blood pressure can slash those risks by as much as a third. That’s where antihypertensive.

Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) This was a study that showed that users of Doxazosin had 25% more CV events and were twice as likely to be hospitalized for heart failure than users of the diuretic, Chlorthalidone.

Diabetic kidney disease affects up to forty percent of patients with diabetes during their lifespan. Prevention and treatment of diabetic kidney disease is currently based on optimal glucose and blood pressure control. Renin–angiotensin aldosterone inhibitors are considered the mainstay treatment for hypertension in diabetic patients, especially in the presence of : Barbara Bonino, Giovanna Leoncini, Salvatore De Cosmo, Eulalia Greco, Giuseppina T.

Russo, Annalisa. Pathophysiology of hypertension in patients with diabetes. Before complications: In those with hypertension and diabetes, there is an expansion of the extracellular fluid volume caused by excessive sodium retention, which is hyperglycaemia-induced and enhanced by hyperinsulinaemia.

4 In addition, the patient is hyper-reactive to both norepinephrine and. Diabetogenic and antidiabetogenic effects of antihypertensive drugs An article from the e-journal of the ESC Council for Cardiology Practice because of its implications in terms of the choice of drugs to employ for initial antihypertensive treatment in seeking to ensure maximal cardiovascular protection for the patient.

it seems that. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J. Antihypertensive effects of ACE inhibitors are due to the reduction in the amount of angiotensin II produced. ACE inhibitors are efficacious in management of hypertension and have a favorable side effect profile.

Antihypertensive drug treatment: no improvement in graft survival Metabolism:nitroprusside. Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study) (MEAD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S. Federal Government. Change in Oral Glucose Tolerance Test (OGTT.

The therapeutic effects of the these drugs are related to their potent cardiovascular effects. They may be used alone or in combination with other drugs such as diuretics in the treatment of hypertension or heart e of their ability to decrease SVR and preload, ACE inhibitors can stop the progression of left ventricular hypertrophy (sometimes seen after a myocardial.

The antihypertensive effects of DEMADEX are on the average greater in black patients than in nonblack patients [see CLINICAL PHARMACOLOGY]. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina.

1 Department of Nephrology, Uludag University Medical Faculty, Bursa, Turkey; 2 Department of Endocrinology and Metabolism, Uludag University Medical Faculty, Bursa, Turkey. In hypertensive diabetic patients, renal angiotensin system blockers are first preferred due to their antihypertensive and antiproteinuric : Muge Erek, Alparslan Ersoy, Canan Ersoy.

96292 views Sunday, November 15, 2020